New Acne Treatments 2024-2025
Acne treatment has undergone a remarkable transformation in the past two years. From the first-ever triple-combination topical treatment to revolutionary laser technology that targets sebaceous glands directly, 2024 and 2025 have brought genuinely innovative options that address acne in ways never before possible.
If you've struggled to find effective acne treatment, felt frustrated by lengthy routines with multiple products, or experienced disappointing results from traditional options, these new developments could be exactly what you've been waiting for.
The Limitations of Traditional Acne Treatment
For decades, acne treatment has followed a familiar pattern: try benzoyl peroxide, add a topical retinoid, perhaps add an antibiotic, and if nothing works, consider isotretinoin (Roaccutane). Whilst these treatments help many people, they have significant limitations.
Traditional treatments often require using multiple separate products in complex routines. Many cause irritation, dryness, and sensitivity, particularly when combined. Oral antibiotics, whilst effective, contribute to antibiotic resistance and can't be used long-term. Isotretinoin is highly effective but comes with significant side effects and strict monitoring requirements.
Additionally, most existing treatments weren't specifically designed for acne – they're repurposed medications developed for other conditions. This is why the new generation of acne-specific treatments represents such a significant advance.
Cabtreo: The First Triple-Combination Topical Treatment
The most significant new development is Cabtreo (clindamycin phosphate 1.2%, adapalene 0.15%, and benzoyl peroxide 3.1%), which received FDA approval in October 2023 and launched in 2024. This is the first and only FDA-approved fixed-dose triple-combination topical treatment for acne.
What makes Cabtreo groundbreaking is that it combines three different mechanisms of action in a single, once-daily application. The clindamycin is an antibiotic that kills acne-causing bacteria. The adapalene is a retinoid that unclogs pores and reduces inflammation. The benzoyl peroxide kills bacteria and prevents antibiotic resistance.
A comprehensive network meta-analysis of 85 studies found that Cabtreo was the most effective topical treatment for moderate-to-severe acne, superior to all other topical therapies, oral antibiotics, and even combinations of these treatments. The only treatment found more effective was oral isotretinoin, which carries a much higher side effect burden.
Crucially, Cabtreo's advanced formulation minimises the irritation typically associated with combining multiple active ingredients. Clinical trials showed fewer reports of burning, stinging, scaling, itching, or redness compared to other acne treatments. This is achieved through an optimised vehicle that enhances tolerability whilst maintaining effectiveness.
The treatment is approved for patients aged 12 and over with moderate-to-severe acne. Whilst it's more expensive than generic individual ingredients, studies show that fixed-dose combinations lead to better adherence and superior outcomes compared to using separate products.
Winlevi: The Only Topical Treatment Targeting Sebum Production
Winlevi (clascoterone 1%) cream represents a completely different approach to acne treatment. Approved by the FDA in 2020 and increasingly prescribed in 2024-2025, it's the only topical medication that directly addresses excessive sebum (oil) production.
Clascoterone works as an androgen receptor blocker applied directly to the skin. Androgens (hormones like testosterone) stimulate sebaceous glands to produce excess oil, which is a key factor in acne development. By blocking androgen receptors in the skin, Winlevi reduces sebum production at the source.
This is particularly valuable because excess sebum production is one of the four fundamental pillars of acne pathogenesis (along with clogged pores, bacteria, and inflammation). Most topical treatments address bacteria and pores but can't reduce oil production – until now.
The American Academy of Dermatology's updated 2024 acne guidelines emphasise treating all four pillars of acne simultaneously for optimal results. Winlevi can be combined with other treatments to create a comprehensive approach targeting every aspect of acne development.
Clinical trials showed Winlevi was well-tolerated with minimal side effects. It's approved for patients aged 12 and over and can be used by both males and females, though it's particularly beneficial for hormonal acne patterns.
Revolutionary Laser Technology: Accure and AviClear
Perhaps the most exciting development in acne treatment is the emergence of 1726 nanometer laser systems, specifically the Accure Laser System and AviClear. These represent the first laser treatments specifically FDA-cleared for long-term acne treatment.
The Accure Laser System received initial FDA clearance in 2022 for treating mild to severe inflammatory acne, becoming the first laser platform approved for this purpose. In October 2024, the FDA expanded this clearance to specifically include long-term treatment, based on clinical trials showing sustained results.
These laser systems work by directly targeting and selectively damaging sebaceous glands using a precise 1726nm wavelength. This is revolutionary because it addresses acne at its source without the systemic side effects of oral medications like isotretinoin.
Clinical trials showed impressive results. After a series of four treatments, patients experienced an average 70% reduction in inflammatory lesions at the six-month follow-up. These results were consistent across all skin types and acne severity levels. Approximately 40% of patients with moderate to severe acne achieved clear or almost clear skin that lasted at least six months post-treatment.
Patient satisfaction was remarkably high, with up to 95% reporting they were very or extremely satisfied with results. The treatment is generally well-tolerated, though some patients experience temporary acne worsening in the first few weeks, which then improves dramatically.
The major advantage over isotretinoin is avoiding systemic side effects like eye dryness, mood changes, and the need for monthly blood tests and pregnancy prevention programmes. For people who cannot or prefer not to use systemic treatments, these lasers offer a game-changing alternative.
Updated Treatment Guidelines: A Paradigm Shift
The American Academy of Dermatology released comprehensively updated acne guidelines in 2024, marking a significant shift in how dermatologists approach treatment. The most important changes include limiting systemic antibiotic use to prevent resistance development and recommending that antibiotics always be used with benzoyl peroxide.
The updated guidelines strongly emphasise treating all four pillars of acne pathogenesis simultaneously rather than adding treatments one at a time. This means starting with combination therapy that addresses clogged pores, bacteria, inflammation, and where appropriate, sebum production.
The guidelines also recognise the importance of early intervention to prevent scarring. Acne scars are permanent, but they're also preventable with appropriate early treatment. The availability of more effective, better-tolerated treatments makes early intervention more feasible.
Another significant change is moving away from automatically defaulting to generic tretinoin prescriptions. Whilst tretinoin remains effective, newer retinoids like adapalene and trifarotene (Aklief) offer improved tolerability and specific advantages. Clinicians are encouraged to consider the full range of available therapies.
Hormonal Treatments: Expanding Options for Women
For women with acne, hormonal treatments have expanded significantly. Whilst combined oral contraceptives (COCs) have been used for years, there's now stronger evidence supporting spironolactone as a first-line treatment option.
Spironolactone, an anti-androgen medication, has demonstrated clinical trial evidence supporting its effectiveness comparable to oral antibiotics but without promoting antibiotic resistance. Recent research positions it as an appropriate first-line systemic treatment for women with acne, particularly those with hormonal patterns (jawline and chin breakouts, premenstrual flare-ups).
The American Academy of Dermatology's 2024 guidelines gave spironolactone a conditional recommendation, acknowledging its effectiveness whilst noting it requires monitoring. Typical doses range from 50-150mg daily, with effects becoming apparent after 2-3 months.
For women already using or considering contraception, three COC formulations are FDA-approved specifically for acne treatment. However, research shows that different COC brands have generally similar efficacy. The choice should be based on contraceptive needs, side effect profile, and individual patient factors rather than acne treatment alone.
Topical clascoterone (Winlevi) offers hormonal acne treatment without systemic effects, making it suitable for people who can't or prefer not to take oral medications.
What About Isotretinoin?
Isotretinoin (Roaccutane/Accutane) remains the most effective treatment for severe, scarring, or treatment-resistant acne. However, the availability of new treatments means fewer people need to use it.
For those who do require isotretinoin, protocols have evolved. Some dermatologists now use lower-dose regimens that maintain effectiveness whilst reducing side effects. Research published in 2024-2025 continues to refine our understanding of optimal dosing strategies.
The new treatments are particularly valuable for people who would benefit from isotretinoin-level effectiveness but can't use it due to pregnancy planning, mental health concerns, or other contraindications. The combination of Cabtreo plus laser therapy, for example, can achieve significant clearance without systemic treatment.
Emerging Treatments on the Horizon
Looking ahead to 2025 and beyond, several promising treatments are in development. A topical treatment derived from Spongilla lacustris (freshwater sponge) extract is being developed as a once-weekly mask with both anti-inflammatory and antimicrobial properties. Early research suggests it may directly address sebaceous gland activity.
PACAP (pituitary adenylate cyclase-activating polypeptide) inhibitors, currently in development for migraine, may have applications in inflammatory skin conditions including acne. Additional novel antibiotics and anti-inflammatory agents specifically designed for acne are in various stages of development.
Microbiome-based treatments that restore healthy skin bacteria rather than simply killing all bacteria are an active area of research. This could revolutionise acne treatment by addressing bacterial imbalance without promoting resistance.
Accessing New Acne Treatments in the UK
Many of these newer treatments are available in the UK, though access varies between NHS and private services. Cabtreo may not yet be widely available on NHS prescription due to cost and formulary restrictions, but private prescriptions can access it.
Laser treatments like Accure are primarily available through private dermatology clinics. Whilst the upfront cost is significant (typically £1,500-£3,000 for a full course), for people who would otherwise use isotretinoin or years of conventional treatments, the cost can be justified.
Winlevi (clascoterone) availability in the UK may be limited, though your dermatologist or private GP can prescribe it. Spironolactone is readily available on both NHS and private prescription for women with appropriate indications.
Online GP services can prescribe most standard acne treatments and provide referrals to dermatology when appropriate. For people struggling to access specialist care through NHS waiting lists, private online consultations offer a faster route to effective treatment.
Creating Your Personalised Treatment Plan
The explosion of new acne treatments means there's no longer a one-size-fits-all approach. The key is finding a doctor who's familiar with the latest options and willing to create a personalised plan based on your specific acne type, severity, skin type, and preferences.
A comprehensive approach for moderate-to-severe acne in 2024-2025 might include a fixed-dose combination topical like Cabtreo as the foundation. For women with hormonal acne, adding spironolactone or a COC. For those seeking alternatives to oral medication, laser therapy targeting sebaceous glands. Prevention of scarring through early, aggressive treatment rather than stepping through multiple failed therapies.
The simplified routines enabled by combination products like Cabtreo improve adherence, which is crucial for success. Using one product once daily is far more sustainable than complex multi-product regimens.
What to Expect from Modern Acne Treatment
With current treatment options, most people should expect significant improvement within 2-3 months of starting appropriate therapy. If you're not seeing meaningful results within this timeframe, your treatment should be reassessed rather than continuing indefinitely with ineffective therapy.
Modern acne treatment should be well-tolerated. Whilst some initial adjustment period with mild irritation is normal with retinoids, severe or persistent irritation indicates the need for formulation changes or additional supportive skincare.
Treatments should address all aspects of your acne, not just one factor. If you're only using an antibiotic, you're missing opportunities to address clogged pores, inflammation, and sebum production.
Taking Control of Your Acne
If you're still struggling with acne despite treatment, or if your current regimen isn't working well, you have more options than ever before. Don't settle for "that's just how acne treatment is" if you're experiencing poor results or unacceptable side effects.
Ask your GP or dermatologist about newer combination treatments like Cabtreo. Enquire about laser therapy if you want to avoid or can't use systemic medications. For women, discuss hormonal options including spironolactone. Seek specialist referral if you're not improving with GP-prescribed treatments.
The goal of acne treatment in 2024-2025 should be clear skin with minimal side effects using the simplest possible regimen. With the treatments now available, this is an achievable goal for most people.
Frequently Asked Questions
Is Cabtreo available on the NHS?
Cabtreo may not yet be widely available on NHS prescription in the UK due to cost and formulary restrictions, as it's a newer branded medication. However, it can be prescribed privately. Some NHS trusts may make it available for specific patients who haven't responded to other treatments. Your GP or online doctor can discuss availability and potentially provide a private prescription if NHS prescribing isn't possible.
How does Cabtreo compare to using separate acne products?
Research shows Cabtreo is more effective than using its individual components separately or in other combinations. The optimised formulation reduces irritation whilst maintaining effectiveness. Studies also demonstrate that fixed-dose combinations improve adherence – people are more likely to stick with one product once daily than multiple products applied separately, leading to better long-term outcomes.
Can I get laser acne treatment through the NHS?
Laser treatments like Accure and AviClear are currently primarily available through private dermatology clinics in the UK. They're not routinely available on the NHS. The cost for a full treatment course typically ranges from £1,500-£3,000. However, for people who cannot use isotretinoin or prefer to avoid systemic treatments, this may be a worthwhile investment with long-lasting results.
Is Winlevi suitable for men with acne?
Yes, Winlevi (clascoterone) is approved for both males and females aged 12 and over. Whilst it works by blocking androgen receptors, it's applied topically to the skin rather than systemically, so it doesn't affect hormone levels throughout the body. It's particularly beneficial for any acne pattern driven by sebum production, regardless of sex.
How quickly do the new acne treatments work?
Cabtreo and other topical treatments typically show initial improvement within 2-4 weeks, with significant results by 8-12 weeks. Laser treatments show progressive improvement, with peak results around 3-6 months after completing the treatment series. Spironolactone for hormonal acne usually takes 2-3 months to show effects. Patience is important – avoid switching treatments too quickly before giving them adequate time to work.
Can I use new acne treatments if I'm pregnant or planning pregnancy?
Topical treatments like benzoyl peroxide and clascoterone are generally considered safer during pregnancy than oral medications. However, topical retinoids including the adapalene in Cabtreo should typically be avoided. Spironolactone is contraindicated in pregnancy. Laser treatments are generally avoided during pregnancy as a precaution. Always inform your doctor if you're pregnant, planning pregnancy, or breastfeeding so they can recommend the safest options.
Why are doctors prescribing fewer antibiotics for acne now?
The 2024 AAD guidelines recommend limiting antibiotic use due to growing antibiotic resistance concerns. Oral antibiotics should be used for the shortest effective duration (typically 3-4 months maximum) and always combined with benzoyl peroxide to prevent resistance. The availability of effective alternatives like combination topicals, laser therapy, and hormonal treatments means fewer people need oral antibiotics.
What's better for severe acne: Cabtreo or isotretinoin?
Isotretinoin remains more effective for severe, scarring, or treatment-resistant acne. However, Cabtreo is the most effective topical option and may be sufficient for many people with moderate-to-severe acne, particularly when combined with other therapies. Cabtreo avoids the significant side effects and monitoring requirements of isotretinoin. Your dermatologist can help determine which is more appropriate for your specific situation.
Can teenagers use these new treatments?
Yes, Cabtreo, Winlevi, and laser treatments are all approved for patients aged 12 and over. Early, effective acne treatment in adolescents is particularly important to prevent scarring and psychological impacts. The improved tolerability of newer treatments makes them especially suitable for younger patients who may struggle with complex routines or side effects.
How can I access these treatments through The Online GP?
Online GP consultations can assess your acne, discuss your treatment history, and prescribe appropriate medications including newer options where available. For treatments requiring specialist input like laser therapy, your online GP can provide referrals. Same-day appointments mean you can start treatment quickly without long waits for NHS dermatology appointments. Private prescriptions give access to newer medications that may not yet be widely available on the NHS.
Struggling with acne and want to explore the latest treatment options? The Online GP offers consultations with doctors who stay current with the newest acne therapies and can create a personalised treatment plan for you.
Message us on WhatsApp now to book your acne consultation – we typically respond within 15 minutes and offer same-day appointments. Get clear skin with modern, evidence-based treatment.
