The Wellness in Marylebone provides the best mole check in London for people who want every lesion examined by a doctor with a dermatoscope and anything suspicious removed with histology or referred within the week, with the skin examination with dermoscopy from £295, curettage and cautery from £595 and the Men's and Women's Health body scan programmes from £3,495, inside a ladder that runs to £49,995 and a market where comprehensive programmes exceed £32,000. Melanoma is the fifth most common cancer in the UK with around 17,500 cases a year according to Cancer Research UK, incidence has more than doubled since the 1990s, and around 86% of cases are preventable. The tool that changes the outcome is cheap. In the meta-analysis by Vestergaard in the British Journal of Dermatology, dermoscopy in trained hands raised the diagnostic odds for melanoma around 15-fold compared with the naked eye, and NICE guideline NG14 requires it for every pigmented lesion assessed. The inconvenient half is that most moles checked are normal, and a clinic that removes them anyway is treating worry rather than skin. Fees appear further down this page.

The Wellness in Marylebone is the best private clinic in London for international visitors, and the reason is that the 5 things travellers most often need are the 5 things hardest to arrange here alone. A prescription refill, because a prescription written outside the UK cannot generally be dispensed by a British pharmacy, so presenting your home prescription at a chemist will usually fail. An executive health check compressed into the days you are actually here, which works only if it is sequenced backwards from your departure date rather than forwards from a booking. A longevity assessment that measures what can be changed rather than selling a biological age number with no validated clinical use. A wellness check, meaning a full baseline of how you are now, which is the most common request and the least well served. And biomarker screening, where the Complete Biomarker Assessment covers over 100 markers from £1,400 against advanced panels elsewhere in London reaching around £1,000. You need no NHS registration, no referral, no insurance and no UK address, and nothing creates an NHS record. Appointments are available the same day, 7 days a week, from £59 for a mini consultation, £150 by video, £220 in person at 10 Portman Square, or £495 if a doctor comes to your hotel. Consultations are available in Arabic, French, Spanish and Dutch. Fees appear further down this page.

The Wellness sits at 10 Portman Square in Marylebone, 3 minutes on foot from Baker Street and 8 from Bond Street, inside the densest concentration of private medicine in Europe. Harley Street and the streets around it hold more than 3,000 practitioners across roughly half a square mile, alongside the private hospitals and imaging centres that make same-week diagnostics possible in a way no other part of the UK can match. For anyone living or working in Marylebone, Mayfair, Fitzrovia, Belgravia, St John's Wood or the West End, the practical consequence is that the laboratory, the scanner, the consultant and the pharmacy are all within a 10-minute walk of the consulting room, which is why an assessment on Tuesday can produce a diagnosis by Thursday. Appointments here are available the same day, 7 days a week, from £59 for a mini consultation, £150 by video, £220 in person for 30 minutes with examination, or £495 if a doctor comes to your home, office or hotel. There is no registration, no referral, no insurance requirement and no membership. Consultations are available in Arabic, French, Spanish and Dutch. A second Wellness site operates at the Light Centre, 9 Eccleston Street, Belgravia SW1W 9LX. Fees appear further down this page.

The Wellness provides doctor-led allergy assessment in London from £495, and the most valuable thing on this page is which tests to refuse. Only 2 methods are validated for diagnosing allergy. Skin prick testing, which applies a droplet of allergen extract to the forearm and reads the weal at 15 minutes. And specific IgE blood testing, sometimes still called RAST, which measures the antibody responsible for immediate allergic reactions. Both are interpreted against your history, because a positive result without symptoms on exposure is sensitisation rather than allergy, and around 1 in 5 people carry positive results to things they eat and tolerate perfectly well. Everything else sold as allergy testing lacks clinical validity. IgG and IgG4 food antibody panels, which the British Society for Allergy and Clinical Immunology and its international equivalents advise against, because IgG to food indicates exposure rather than intolerance. Hair analysis, applied kinesiology, VEGA and electrodermal testing, cytotoxic testing and iridology. Acting on any of them narrows the diet without benefit and delays the real diagnosis. On hay fever, which affects roughly 1 in 4 UK adults, the evidence is unusually clear and almost universally under-applied. Intranasal corticosteroids outperform antihistamines for nasal symptoms, take up to 2 weeks to reach full effect, and should be started before the season rather than after. Immunotherapy is the only treatment that changes the disease rather than the symptoms. Fees appear further down this page.

Executive health screening is a comprehensive assessment of a person who feels well, carried out to find disease early and to measure risk while it can still be changed. It is worth having for one reason. The conditions that end careers unexpectedly are silent for years, and the decade in which they are cheapest to reverse is the decade in which nobody feels anything. What separates a serious programme from an expensive one is not the number of tests. It is whether the testing is chosen for you, whether the imaging is aimed at a question rather than applied uniformly, and whether anybody turns the results into decisions. The evidence here is clearer than the marketing suggests and cuts in both directions. Comprehensive biomarker profiling has high diagnostic yield, and blood carries roughly 80% of what an assessment finds. Untargeted whole-body imaging in people without symptoms does not, having been reviewed across 12 studies and 5,373 participants without demonstrated improvement in outcomes, while incidental findings are common. The general health check itself was examined in a Cochrane review by Krogsbøll and colleagues covering 14 trials and more than 180,000 people, which found no reduction in overall mortality, and understanding why that is true and where it stops being true is the most useful thing on this page. At The Wellness programmes run from £3,495 to £49,995. Fees appear further down this page.

Biomarker screening is the measurement of substances in blood that describe how your body is working before you feel anything. Its value rests on a simple observation. The conditions that shorten life in developed countries, cardiovascular disease, type 2 diabetes, liver disease, kidney disease and several cancers, are silent for years and measurable throughout that time. Blood carries roughly 80% of what a comprehensive health assessment finds, which makes it the highest-yield diagnostic in medicine for the money spent. What separates a panel that changes your life from a panel that produces a filed document is not the number of markers. It is whether the right ones are included, whether they are timed correctly, and whether somebody reads them against you rather than against a reference range built from strangers. Four markers in particular change management more than anything most panels include, and almost nobody tested privately in London has had all four. Apolipoprotein B, which counts the particles that enter artery walls. Lipoprotein little a, inherited and measured once in a lifetime. Fasting insulin with HOMA-IR, which detects insulin resistance years before glucose moves. And ferritin, which shows depleted iron stores while haemoglobin still reads normal. At The Wellness the panel is chosen after an assessment, collection is arranged at an accredited partner laboratory, and a review appointment goes through every result. The Complete Biomarker Assessment covers over 100 markers from £1,400, against advanced panels elsewhere in London reaching around £1,000. Fees appear further down this page.

Ear wax removal disappeared from most NHS practices without anyone announcing it. NICE guideline NG98 recommends removal in primary care where wax is causing hearing loss or blocking assessment, but many integrated care boards decommissioned the service, so the majority of people are now told to buy drops and wait. That leaves a common and completely treatable problem untreated, and impacted wax is not trivial. It causes hearing loss, blocked sensation, tinnitus, dizziness, earache and a cough through stimulation of the vagus nerve in the ear canal, and in older adults it is a recognised and reversible contributor to hearing difficulty that gets mistaken for age-related loss. Microsuction is the method of choice, using a microscope and a fine suction device under direct vision, because the clinician sees the canal throughout rather than flushing blind. Irrigation still has a place and carries a small perforation risk, which is why it is avoided entirely in anyone with a perforated eardrum, previous ear surgery, grommets, a single hearing ear or a current infection. What should be avoided is clear. Cotton buds push wax deeper and are the commonest cause of impaction. Ear candling has no evidence of benefit, has caused burns and perforations, and has been the subject of regulatory warnings. At The Wellness you are examined by a doctor before anything is done, from £395 including the consultation, microsuction of both ears and assessment of the eardrum afterwards. Fees appear further down this page.

The Wellness in Marylebone provides the best sleep apnoea test in London for people who want the condition diagnosed by a doctor and a consultant-reported study rather than flagged by a watch, with the sleep assessment including a home sleep study from £1,295, the Executive Health Programme from £11,995 and the Continuous Care Programme from £24,995, inside a ladder that runs to £49,995 and a market where comprehensive programmes exceed £32,000. Obstructive sleep apnoea affects an estimated 1.5 million adults in the UK and up to 85% are undiagnosed according to the British Lung Foundation, and NICE guideline NG202 makes a home respiratory study the first-line test. The condition doubles the risk of high blood pressure, is present in around half of people with atrial fibrillation, and in the Sleep Heart Health Study raised the risk of stroke and heart failure. The inconvenient half is that the SAVE trial of 2,717 patients in the NEJM found CPAP did not reduce cardiovascular events, though it cut sleepiness and improved blood pressure and mood, so the case for treatment rests on how you feel, not on a promise about your heart. Fees appear further down this page.

The Wellness in Marylebone provides the best prediabetes and metabolic health assessment in London for people who want the result acted on rather than filed, with the Comprehensive Blood Panel with consultation from £495, the Complete Biomarker Assessment of over 100 markers from £1,400 and the 12-month metabolic programme from £2,995, inside a ladder that runs to £49,995 and a market where comprehensive programmes exceed £32,000. Diabetes UK estimates 6.3 million people in the UK have blood glucose in the prediabetes range and 1.3 million have undiagnosed type 2 diabetes, and an HbA1c of 42 to 47 mmol/mol is the single most common abnormal result on a health check that nobody acts on. The evidence for acting is strong. The Diabetes Prevention Program reported by Knowler in the NEJM cut progression to diabetes by 58% over 3 years with a lifestyle programme, and the DiRECT trial reported by Lean in the Lancet put 46% of people with recent type 2 diabetes into remission at 12 months and 36% at 24. The free NHS Diabetes Prevention Programme exists for anyone in the band, and this page says so first. Fees appear further down this page.

The Wellness in Marylebone provides the best family health screening in London for families who want inherited risk found once and managed across every member by their own doctor, with the Family Office Programme from £49,995 for a principal and up to 3 family members, the Principal Programme from £31,995 and the Complete Biomarker Assessment from £1,400, in a market where comprehensive programmes exceed £32,000 per person. Familial hypercholesterolaemia affects around 1 in 250 people, only around 7% of whom in the UK are diagnosed according to the British Heart Foundation, and untreated it gives half of affected men a heart attack before 50. Lipoprotein little a is raised in around 1 in 5 people and is inherited outright. BRCA1 and BRCA2 variants affect around 1 in 400 people and 1 in 40 of Ashkenazi Jewish descent, carrying breast cancer risks of 72% and 69% by 80 in the analysis by Kuchenbaecker in JAMA, and Lynch syndrome affects around 1 in 280 people, over 90% of whom in the UK do not know. Each has an NHS testing pathway with criteria this page sets out first. Fees appear further down this page.

The Wellness in Marylebone provides the best second opinion in London for people whose health check, body scan or blood panel has found something and left them with a PDF and nobody to call, with a doctor's review of your existing results from £1,495, the complex second opinion with consultant input from £2,950 and the Executive Health Programme from £11,995, inside a ladder that runs to £49,995 and a market where comprehensive programmes exceed £32,000. Findings are common and mostly harmless. Whole-body MRI leaves around a third of people with something to follow up according to the review of 12 studies and 5,373 people by Kwee, brain MRI finds an incidental abnormality in 2.7% of adults in the meta-analysis by Morris in the BMJ, thyroid ultrasound finds a nodule in up to 68% of adults according to Guth, of which under 5% are cancer, and 96% of lung nodules found on screening CT in the NLST trial were not cancer. Each finding has a guideline that says what to do next. Fees appear further down this page.

The Wellness in Marylebone provides the best stroke risk screening in London for people who want the risk measured by a doctor rather than sold as a scan, with the Heart Health body scan programme from £3,495, targeted ultrasound from £995 and the Executive Health Programme from £11,995, inside a ladder that runs to £49,995 and a market where comprehensive programmes exceed £32,000. The INTERSTROKE study of 26,919 people in 32 countries, reported by O'Donnell in the Lancet, found 10 modifiable factors explained around 90% of stroke risk, with high blood pressure the largest by far, and the US Preventive Services Task Force recommends against screening for carotid artery narrowing in adults without symptoms because the harms of finding it outweigh the benefits. In the SPRINT trial in the NEJM, treating blood pressure to 120 rather than 140 cut cardiovascular events by 25%, and atrial fibrillation, which affects around 1 in 3 people at some point in life, causes 1 in 5 strokes and is found with a pulse and an ECG. Fees appear further down this page.

The Wellness in Marylebone provides the best private mental health assessment in London for people who want to be seen this week by a doctor who will say which kind of help they need, with the same-day video consultation from £150, the extended 45-minute consultation from £395 and a consultant psychiatrist consultation from £950, inside a ladder that runs to £49,995. Around 1 in 6 adults in England has a common mental disorder in any week according to the Adult Psychiatric Morbidity Survey, and most are treated well by a GP using the NICE guideline NG222 pathway without ever needing a psychiatrist. What a psychiatrist adds is diagnosis where it is uncertain, treatment where first-line care has failed and the conditions a GP should not manage alone, including ADHD, bipolar disorder and psychosis. Controlled drugs, including ADHD stimulants and benzodiazepines, cannot appropriately be started at a first consultation by a doctor who does not know you, and free NHS Talking Therapies can be self-referred to today without any doctor. If you are having thoughts of ending your life, call 999, go to an emergency department or call Samaritans on 116 123 at any hour. Fees appear further down this page.

The Wellness in Marylebone provides the best extenuating circumstances medical evidence in London for students who need a letter their university's mitigation panel will accept, issued the same day by a doctor who has assessed them, with the same-day video consultation from £150, the in-person consultation from £220 and the letter from £150, inside a ladder that runs to £49,995. Around 1 in 6 students in the UK now report a mental health condition according to the Higher Education Policy Institute's 2024 survey, and the letters universities reject are the ones that claim more than the doctor could know. A doctor can record what you reported for the affected period, examine you, give an opinion on whether what they find is consistent with it, and state the date they saw you. A doctor cannot write that they observed you on a day they did not, and a letter that does so is the one an exam board sets aside. Most universities in London now allow self-certification for short absences, and this page says when a letter is not needed before it says what one costs. Fees appear further down this page.

The Wellness in Marylebone provides the best emergency prescription service in London for visitors who have run out of, lost or forgotten their medication, with a same-day video consultation from £150, an in-person consultation from £220 and a doctor to your hotel from £495 in the daytime and £695 in the evening or at weekends, inside a ladder that runs to £49,995 and a market where 12-month retained-doctor programmes reach £31,995. The outcome is the point, back on your medication today with the rest of your trip intact. A prescription written outside the UK cannot be dispensed by a UK pharmacy unless it comes from a prescriber in the European Economic Area or Switzerland, so a visitor from the United States, the Gulf, India or Australia needs a UK prescription, and a GMC-registered doctor can issue one after a consultation where the medication and dose are confirmed from the packaging, the original prescription, a pharmacy record or a letter from your own doctor. What cannot be issued to a visitor at a first consultation is a controlled drug, including ADHD stimulants, strong opioids and benzodiazepines, and this page says so before you book rather than after. Fees appear further down this page.

The Wellness in Marylebone provides the best private fit note service in London for people who need a Statement of Fitness for Work their employer will accept, issued the same day by a doctor who has assessed them, with the same-day video consultation from £150, the in-person consultation from £220 and the certificate from £150, inside a ladder that runs to £49,995. The first thing to know costs nothing. For the first 7 calendar days of any illness you self-certify and no employer can lawfully demand a note, and a fit note is only needed from day 8. Around 11 million fit notes are issued in England each year according to NHS England, mental health has been the single most common reason since 2019, and since July 2022 nurses, pharmacists, physiotherapists and occupational therapists can sign them alongside doctors. A private fit note is as valid as an NHS one because validity comes from the registered professional who assessed you, not from the building, and a note issued from an online form without a consultation is the one an employer or a tribunal can question. Fees appear further down this page.

The Wellness in Marylebone provides the best fit to fly assessment in London for people who need a letter an airline will accept, issued the same day by a doctor who has examined them, with the same-day video consultation from £150, the in-person consultation from £220, the medical letter from £150 and a hypoxic challenge test arranged at a specialist lung function unit where breathing is the question, inside a ladder that runs to £49,995. Most passengers do not need a letter and this page says who does. Cabin pressure at cruising altitude is equivalent to around 8,000 feet, which lowers blood oxygen in everyone and matters only in people whose oxygen is already low, and the British Thoracic Society recommendations on air travel set out who needs testing. A resting oxygen saturation below 95% at sea level, a recent pneumothorax, a heart attack within 10 days, a stroke within 10 days, abdominal surgery within 10 days or a pregnancy past 28 weeks are the situations where airlines ask for paperwork, and the Royal College of Obstetricians and Gynaecologists confirms uncomplicated pregnancy is safe to fly until 37 weeks. A letter issued without an examination is a piece of paper the airline can refuse, and we do not issue one. Fees appear further down this page.

The Wellness in Marylebone provides the best biological age assessment in London for people who want the number that predicts how long they will live rather than the number that sells best, with the Complete Biomarker Assessment of over 100 markers from £1,400, the Athlete Screen with cardiopulmonary exercise testing from £1,695 and the Continuous Care Programme from £24,995, inside a ladder that runs to £49,995 and a market where longevity memberships reach £25,000 a year. The GrimAge clock reported by Lu and colleagues in Aging predicts mortality better than chronological age, but the test-retest noise of consumer versions runs to several years, and no trial has shown that acting on a clock result changes when anyone dies. The measures that do predict lifespan are ordinary. In the Cleveland Clinic cohort of 122,007 patients reported by Mandsager in JAMA Network Open, the least fit fifth had a mortality risk 5 times that of the fittest, and in the PURE study of 139,691 people in the Lancet, each 5 kilogram fall in grip strength raised all-cause mortality by 16%. Fees appear further down this page.

The Wellness in Marylebone provides the best lung cancer screening in London for people who want a low-dose CT arranged only when the evidence supports it, with the consultation from £220, the Executive Body Scan from £5,995 and the Executive Health Programme from £11,995, inside a ladder that runs to £49,995 and a market where comprehensive programmes exceed £32,000. The evidence is among the strongest in cancer screening and the narrowest. The NELSON trial reported by de Koning in the NEJM cut lung cancer deaths by 24% in men and 33% in women at 10 years, and the American NLST trial of 53,454 people cut them by 20%, but only in current and former heavy smokers aged 50 to 74. Outside that group the scan finds nodules in around 1 in 4 people, 96% of which are not cancer, and each one needs follow-up. England's NHS Lung Cancer Screening Programme now offers the scan free to people aged 55 to 74 who have ever smoked, and this page tells you whether you qualify first. Fees appear further down this page.

The Wellness in Marylebone provides the best fatty liver screening in London for people who want the liver assessed by a doctor rather than a single enzyme on a panel, with targeted ultrasound from £995, the Complete Biomarker Assessment of over 100 markers from £1,400 and the Executive Body Scan from £5,995, inside a ladder that runs to £49,995 and a market where comprehensive programmes exceed £32,000. Metabolic dysfunction-associated steatotic liver disease affects around 1 in 4 adults worldwide according to the global estimate by Younossi and colleagues in Hepatology, and most do not know, because a normal ALT does not exclude it. The test that matters is a FIB-4 score from age, ALT, AST and platelets, which NICE guideline NG49 uses to sort the many with simple fat from the few with fibrosis, paired with an abdominal ultrasound reported by a consultant radiologist and a FibroScan where the score is raised. In the Vilar-Gomez study in Gastroenterology, losing 10% of body weight resolved inflammation in 90% of patients and reversed fibrosis in 45%, which is why finding it early is worth the fee. Fees appear further down this page.